Anabolicki preparati

The anabolic actions of GH in GH-deficient adults and children are well documented. Replacement with GH in such individuals promotes protein synthesis and reduces irreversible loss of protein through oxidation. Although GH is known to be self-administered by athletes, its protein metabolic effects in this context are unknown. This study was designed to determine whether 4 wk of high dose recombinant human GH (r-hGH) administration altered whole body leucine kinetics in endurance-trained athletes at rest and during and after 30 min of exercise at 60% of maximal oxygen uptake. Eleven endurance-trained male athletes were studied, six randomized to receive r-hGH ( mg/), and five to receive placebo. Whole body leucine turnover was measured at rest and during and after exercise, using a 5-h primed constant infusion of 1-[(13)C]leucine, from which rates of leucine appearance (an index of protein breakdown), leucine oxidation, and nonoxidative leucine disposal (an index of protein synthesis) were estimated. Under resting conditions, r-hGH administration increased rate of leucine appearance and nonoxidative leucine disposal, and reduced leucine oxidation (P < ). This effect was apparent after 1 wk, and was accentuated after 4 wk, of r-hGH administration (P < ). During and after exercise, GH attenuated the exercise-induced increase in leucine oxidation (P < ). There were no changes observed in placebo-treated subjects compared with the baseline study. We conclude that GH administration to endurance-trained male athletes has a net anabolic effect on whole body protein metabolism at rest and during and after exercise.

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U nastanku akni značajni su slijedeći faktori: genetika, veličina i aktivitet žljezda lojnica, poremečaj keratinizacije, bakterije, hormoni te psihosocijalni aspekti. Prema težini bolesti razlikujemo više oblika akni:
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U liječenju akni primjenjuje se čitav niz metoda i pripravaka, ovisno o stupnju bolesti i uzrocima nastanka. Akne se najčešće javljaju kod mladih. Više od 80% adolescenata ima neke znakove akni, oba spola podjednako. Prve akne se mogu pojaviti već sa 8 godina, no najviše između 13 i 15 godina. Akne se najčešće javljaju u pubertetu zato jer u tom razdoblju u tijelu djevojaka i mladića stvara se previše muških hormona koji dovode do povećane produkcije u lojnicama. Istodobno zatvaraju se izvodni kanali lojnica i izlučeni se loj miješa s odumrlim rožnatim stanicama. Nastaje zastoj čiji su rezultati komedoni ili miteseri. Utjecajem mikroorganizama Propyonibacterium acnes dolazi do razgradnje loja u komedonima pri čemu nastaju slobodne masne kiseline koje iritiraju tkivo. Nastaju upala s crvenilom, bolnim prištićem veličine papra do graška. Tijek bolesti je kroničan s pogoršanjima i poboljšanjima. Nakon puberteta često nestaju, ali mogu potrajati i do 30 godina i dulje. Uzimanje lijekov ponekad dovodi do medikamentoznih akni, te nakon uzimanja joda, broma, kortikosteroida, anabolika, itd. te visokih doza vitamina B i D. Katkad je uzrok "kasnih akni" u poremečenoj funkciji hormonalnih žljezda. Neki kozmetički proizvodi mogu izazvati akne. To su preparati koji iritiraju izvodne kanale lojnica i uzrokuju stvaranje mitesera.
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Anabolicki preparati

anabolicki preparati

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