Axis pharmaceuticals steroids

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The adenosine that tumors produce interacts with adenosine receptors on the surface of invading immune cells. A type of adenosine receptor known as A2A is expressed on several cells of the immune system, including T-cells, NK cells, macrophages and dendritic cells. Binding of adenosine to the A2A receptor has the effect of dampening the ability of the immune cells to attack tumors. A significant body of scientific data indicates that targeting the adenosine-cancer axis through the A2A receptor can promote anti-tumor immune responses to occur, leading to tumor regression.

We are a clinical stage biopharmaceutical company focused on the development and commercialization of novel immuno-oncology therapies that are designed to harness the immune system to attack cancer cells. Since we began operations in November 2014, we have built a pipeline of four immuno-oncology programs, three of which focus on the adenosine-cancer axis to modulate an immune response. Our lead product candidate, CPI-444, is an oral, small molecule antagonist of the A2A receptor for adenosine, an immune checkpoint. In January 2016, we began enrolling patients in a large expansion cohort trial for CPI-444. This Phase 1/1b clinical trial is designed to examine safety, tolerability, biomarkers and preliminary efficacy of CPI-444 in several solid tumor types, both as a single agent and in combination with Genentech, Inc.'s investigational cancer immunotherapy, Tecentriq® (atezolizumab), a fully humanized investigational monoclonal antibody targeting PD-L1.  ... More ...  

Farooqi has collaborated with Boston-based Rhythm Pharmaceuticals to test the company's potential therapeutic called setmelanotide, which acts on the hypothalamus to activate MC4R. In January, Rhythm Pharmaceuticals announced that the drug had received breakthrough therapy designation from the FDA for the treatment of obesity caused by POMC deficiency. The designation means that setmalontide can undergo an expedited review by the agency, and it is the first such designation from the FDA's Division of Metabolism and Endocrinology Products.

Axis pharmaceuticals steroids

axis pharmaceuticals steroids

Farooqi has collaborated with Boston-based Rhythm Pharmaceuticals to test the company's potential therapeutic called setmelanotide, which acts on the hypothalamus to activate MC4R. In January, Rhythm Pharmaceuticals announced that the drug had received breakthrough therapy designation from the FDA for the treatment of obesity caused by POMC deficiency. The designation means that setmalontide can undergo an expedited review by the agency, and it is the first such designation from the FDA's Division of Metabolism and Endocrinology Products.

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