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"One of the primary effects of ketamine in the brain is to block the NMDA [N-methyl-d-aspartate] glutamate receptor," said James W. Murrough , MD, principal investigator of the study, and Assistant Professor of Psychiatry and Neuroscience , and Associate Director of the Mood and Anxiety Disorders Program at the Icahn School of Medicine at Mount Sinai. "There is an urgent clinical need for new treatments for depression with novel mechanisms of action. With further research and development, this could lay the groundwork for using NMDA targeted treatments for major depressive disorder."

The trials of intranasal insulin vary in that some test fast-acting forms of insulin as used in diabetes therapy, while others evaluate longer-acting insulin analogs. For example, two trials conducted at the University of Washington in Seattle between 2011 and 2013 evaluated insulin detemir, a long-acting insulin analog that differs from human insulin by one amino acid. A three-week study in 60 patients with MCI or AD compared 10 and 20 IUs of insulin detemir twice daily to placebo.  A subsequent four-month study then compared 20 IUs twice daily of insulin detemir to 20 IUs of regular insulin twice daily in 90 patients. Both trials looked for effects on a memory composite and six different secondary outcomes; results are not yet published.

Alpha Omega Alpha Honor Medical Society
American Academy of Neurological Surgery
American Association for the Advancement of Science
American Association of Neurological Surgeons
American College of Surgeons
American Epilepsy Society
American Heart Association
American Society of Neuroimaging
American Society of Stereotactic and Functional Neurosurgery
Chicago Medical Society
Chicago Neurological Society
Chicago Society of Neuroscience
Chilean Society of Neurosurgery
Congress of Neurological Surgeons
International College of Surgeons
International Platform Association
New England Neurosurgical Society
New York Academy of Sciences
North American Skull Base Society
Research Society of Neurological Surgeons
Societe de Neurochirurgie de Langue Francaise
Society of Neurological Surgeons (Senior Society)
International College of Surgeons
World Society of Functional and Stereotactic Neurosurgery
World Association of Lebanese Neurosurgeons
Yale Surgical Society

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