Braun et al (2002) reported the results of a 12-week randomized placebo-controlled clinical trial involving 35 patients with active ankylosing spondylitis treated with intravenous 5 mg/kg infliximab infusion (at weeks 0, 2 and 6) and 35 patients assigned to placebo. Eighteen (53 %) of 34 patients on infliximab had a regression of disease activity at week 12 of at least 50 % compared with 3 (9 %) of 35 on placebo (difference 44 % (95 % confidence interval [CI]: 23 to 61, p < ). Function and quality of life also improved significantly on infliximab but not on placebo (p < and p < , respectively). The investigators reported that treatment with infliximab was generally well-tolerated, but 3 patients had to stop treatment because of systemic tuberculosis, allergic granulomatosis of the lung, or mild leucopenia.
“Cézanne is the finest expressions of this decadence. He was truly unable to imitate the masterpieces and all of his admired technique is merely proof of his inability. His apples are made of cement. The paradox is that what is least admirable is most admired: nullity! What a symbol for a period! On the pretext of the academic being detestable, the worst in the class was made a hero! He opens the door to the ethics of shit! Newness at whatever costs and art becomes just a latrine! The logic of this search for newness leads to the gratification of total shit of which Cézanne is the high priest.” – Salvador Dalí (Dalí on Modern Art, 1957)