Topical gels have been shown to reduce the need for oral analgesics which is a good thing for reducing side trial found that topical capsaicin reduce pain more than placebo in people with AS, although it can cause burning sensations. Another trial used a gel form of a drug called tenoxicam (an NSAID) that suggested it might be helpful. Do ask your specialist if you can try something like voltarol – or a stronger version on prescription – and follow their individual advice. They may prefer you to have some oral anti-inflammatory on board to reduce inflammation throughout the body, however.
In some cases, those with extremely sensitive or thin skin have reported that creams containing dimethicone can make their skin feel drier than usual. This a paradoxical effect, as the ingredient is supposed to moisturize the skin, but the intricacies in individual genetics and biology can play a big role in how your skin reacts to any skin care ingredient. If this severe dryness should occur, it is usually an indicator that you have a sensitivity or allergy to the chemical. To reduce the risk of sensitivity, limit the use of products that contain this ingredient and maybe even try a homemade wrinkle cream instead. Keep in mind, however, that some experts believe that this chemical may even interact with herbal topical medicines. If you have any concerns about dimethicone or its effects on the skin, you may want to consult your physician in addition to a dermatologist, as this chemical has been known to accumulate in the body with prolonged use.
As well, parabens were found in breast cancer tissue. But that's all we know, it was there. It was never proven (esp in many subsequent studies) to have a conclusive link to cancer, and for all we know it is found in much higher concentrations in your left big toe. Obviously I'm playing devil's advocate, but we really don't know anything. It's much easier to avoid parabens now than it used to be, so if you're concerned I say to avoid them. But, when listening to the advice of others (including me), just consider what their alternative agenda is. I guess mine is that I don't mind parabens for myself, but I also want consumers to know what studies really found. The EWG is a lobbyist group, and they very frequently overstate or completely misstate what studies find, so they make a lot of people much too worried/freaked out.