Pseudosepsis has been characterized as severe joint inflammation with pain and effusion occurring 24 to 72 hours after injection and it may be more likely to occur after the second or third injection or with repeated courses. Nonsteroidal anti-inflammatory drugs, intra-articular steroids, and/or arthrocentesis are often required to treat pseudosepsis.
In a double-blind, controlled trial involving 226 patients with knee osteoarthritis the most frequent cause of discontinuation of sodium hyaluronate therapy was worsening of knee pain (11% vs. 13% with saline). [ Ref ]
An urgent care center is used for episodic care for patients with medical conditions that require treatment. When experiencing a non-life threatening situation (but could lead to potentially harmful outcome if not treated in a timely fashion), a patient can receive treatment at Methodist Urgent Care rather than seeking treatment at an emergency room. Patients should inform their Primary Care physician of such visit and consult him or her for follow up care. If the patient is in a life-threatening situation, please call 911 right away for care.