DuoTrav has been studied in five main studies involving a total of 1,482 patients (aged 18 to 91) with open-angle glaucoma or ocular hypertension. The studies lasted between six weeks and 12 months. One study compared DuoTrav taken in the morning with DuoTrav taken in the evening. Three studies compared DuoTrav with travoprost and timolol either given on their own, or together but as separate eye drops. The fifth was a 12-month study that compared DuoTrav with eye drops containing a combination of latanoprost (another prostaglandin analogue) and timolol.
Within this class, the alpha2 selective agonist brimonidine is the most commonly used for the treatment of ocular hypertension.  Apraclonidine is another alpha2-selective agonist, but it is believed to have more of an allergic potential, so it rarely is used as a long-term medication. Less selective adrenergics, such as epinephrine and dipivefrin, can have a significantly higher allergic component and other substantial adverse effects, such as exacerbation of hypertension, angina, palpitations, and cystoid macular edema. Because these less selective agents are used infrequently in treating ocular hypertension, they are not discussed here. Alpha2 adrenergic agonists work by decreasing aqueous production.