The 17α-methylation of the steroid does allow it to pass through the liver with only a small portion of it broken down (hence causing the aforementioned damage to the liver) allowing it to be effective when taken orally. It also has the effect of decreasing the steroid’s affinity for sex hormone-binding globulin, a protein that deactivates steroid molecules and prevents them from further reactions with the body. As a result, metandienone is significantly more active than an equivalent quantity of testosterone, resulting in rapid growth of muscle tissue. However, the concomitant elevation in estrogen levels – a result of the aromatization of metandienone – results in significant water retention. This gives the appearance of bad gains in mass and strength, which proves to be temporary once the steroid is discontinued and water weight drops. Because of this, it is often used by bodybuilders at the start of a “steroid cycle”, to facilitate rapid strength increases and the appearance of great size, while compounds such as testosterone cypionate or testosterone enanthate with long acting esters build up in the body to an appreciable amount capable of supporting anabolic function on their own.
I have always been the skinny guy in the crowd, but when I hit 21 I decided that was going to change. I started with a strict diet and lifting regimen, but it’s been slow going. I really began to suspect that low T was the culprit. At the advice of a friend, I replaced my herbal supplements with Prime Male. Since then, I have been putting on muscle faster. I have gone from a skinny guy to someone who can’t find a t-shirt that will fit my arms thanks to this little boost to my lifting. I finally feel like I am achieving the bulk and definition that I have wanted my whole life. – Zack T., Colorado, US