Eye care practitioners can choose from an impressive and effective armamentarium of drugs to combat infectious diseases that are caused by bacteria. In most cases, a combination steroid-antibiotic agent is the best choice to address both the infection (or the threat of infection) and the inflammation that results from bacterial inhabitation. High-dose, potent antibiotic therapy should be reserved only for those serious infectious cases where the cornea is truly threatened and should never be used injudiciously because of the evergrowing risk of antibiotic-resistant organisms.
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Uveitis : Controlled clinical studies of patients with uveitis demonstrated that LOTEMAX (loteprednol etabonate ophthalmic suspension) was less effective than prednisolone acetate 1%. Overall, 72% of patients treated with LOTEMAX (loteprednol etabonate ophthalmic suspension) experienced resolution of anterior chamber cell by day 28, compared to 87% of patients treated with 1% prednisolone acetate. The incidence of patients with clinically significant increases in IOP ( ≥ 10 mmHg) was 1% with LOTEMAX (loteprednol etabonate ophthalmic suspension) and 6% with prednisolone acetate 1%.