Prostaglandin analogs may cause changes in iris color and eyelid skin, growth of eyelashes , stinging, blurred vision , eye redness, itching, and burning. Beta blockers' side effects include low blood pressure , reduced pulse rate , fatigue , shortness of breath, and in rare occasions, reduced libido and depression . Alpha agonists can cause burning or stinging, fatigue, headache , drowsiness , dry mouth and nose , and also they have a higher likelihood of allergic reaction. Carbonic anhydrase inhibitors may cause stinging, burning, and eye discomfort. 
Visine and many other over-the-counter (OTC) eye drops are not good choices for the treatment of eye allergies . Many OTC eye drops contain topical decongestants, such as naphazoline and tetrahydrozoline, which act to decrease redness of the eyes. Some OTC eye drops combine topical decongestants and topical antihistamines, such as found in Visine-A and Opcon-A. While these various eye drops are effective for the short-term relief of eye redness, as well as eye itching when the topical antihistamine is added, the long-term use of topical decongestants can lead to side effects.
Meibomian gland dysfunction is caused by the blockage of the meibomian glands in the eyelid. As a result, they don’t secrete enough oil into the tears to keep the eyes moist. This causes the tears to then evaporate too quickly, making it a leading cause of dry eye syndrome. Options for relief include manual gland probing (a doctor presses the hardened gland open with an instrument), antibacterial eye drops, and modifying the body’s immune response with a drug called Cyclosporine. Dipyridamole pinguecula eye drops have also proven effective for this condition, and have no known side effects.
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