A 67-year-old female patient who had lower quadrant pain for a week was assessed with abdominal CT and colonoscopy. Computed tomography revealed diffuse tumoral wall thickness in 10 cm segment of distal ascending colon. There was 13x9 mm in size a necrotic space in the central of lesion. Mesenteric adipose tissue was seen as heterogeneous. CT findings were evaluated as T3 colon tumor. Neither lymph node or liver metastases or mesenteric vascular pathology were not seen. Colonoscopy demonstrated bloody, vegetan mass which did not let the endoscope pass. Laparoscopic right hemicolectomy was performed. After surgery, there was no tumor in histopathologic examination. Microscopy revealed chronic inflammation and findings of closed perforation. There was no lymph node involvement. The patient had history of using NSAID for two months. This pathology was diagnostically challenging because of its similar endoscopic and CT findings with ischemic, inflammatory/ infectious bowel disease or neoplasia. Hence this pathology should be kept in mind in order to differentiate the diagnosis, especially in patients with a history of NSAID use.