Thus a local conformational change initiated by the agonist, but not antagonist binding results in a destabilization of the protein structure. This destabilization is not strong enough to denature the protein, but results in a long range effect across the protein affecting its active site several angstrom away from the ligand binding site. This is known as an allosteric mechanism. As a rule, agonists induce structure destabilization, while antagonists merely bind , but do not affect the protein structure (or trigger a conformational change that locks a protein in its inactive position). One way to visualize the action of ligands on receptors is to realize that proteins constantly undergo conformational changes which is best described as an equilibrium between an active and inactive, or even among multiple states, including desensitized states (different types of inactive states). Agonists and antagonists shift this equilibrium towards an active or inactive conformation, respectively.
Q. The HIV test came back POSITIVE! My very close friend 'Demonte'. One day in December as he was returning from a business trip, his wife met him at the airport with terrible news. During a routine pregnancy check up, her doctor had administered an HIV test along with other blood-work. The HIV test came back POSITIVE! The doctor wanted to begin administering drugs immediately but the cost of these drugs here when compared to their family income was prohibitive. I helped him with some of my savings. He already sold his favorite sentimental car to save his precious wife. Now i want to know is there any NATURAL medicine to cure this? Hope it costs less and available. A. there are no effective natural remedy for HIV. the medications are very hard ones that try to control the virus from spreading (cannot eliminate it though). no herbal remedy or nutrition change will do that.
Ashwagandha is an herb noted for its ability to calm nerves and improve sleep. It is an amphoteric adaptogen with anti-inflammatory and antioxidant qualities that regulate the neuroendocrine system. Ashwagandha contains alkaloids, steroidal lactones and saponins active in the hormonal pathways in the body. These constituents increase T4 hormone production and help with the conversion of T4 to T3. Ashwagandha also increases hepatic glucose-6 phosphatase and reduces lipid peroxidation of hepatic tissues. 1 These processes help protect the liver and detoxification pathways.